MYBL2

MYBL2 is a gene that encodes a member of the MYB family of transcription factors. The protein produced by this gene includes three domains: an N-terminal domain, a central DNA-binding domain, and a C-terminal domain. The protein functions as a transcription factor during cellular proliferation and may be necessary for the formation of the proper number of cells in certain tissues.

Function

MYBL2 is a member of the MYB family of transcription factors and is involved in cell cycle regulation. The protein encoded by this gene is a key component of the G2/M phase transition of the cell cycle. It binds to the promoters of genes that are necessary for progression through the cell cycle and activates their transcription.

Clinical significance

Alterations in the MYBL2 gene have been associated with a variety of cancers. Overexpression of MYBL2 has been observed in breast cancer, colorectal cancer, and lung cancer, among others. In addition, MYBL2 has been implicated in the development of leukemia and lymphoma.

Research

Research into the role of MYBL2 in cancer has led to the development of potential therapeutic strategies. For example, inhibitors of MYBL2 have been proposed as potential treatments for certain types of cancer.

See also

• MYB (gene)
• Transcription factor
• Cell cycle
• Cancer

References

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