Mannitol 2-dehydrogenase (NADP+)

Mannitol 2-dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction of D-mannitol + NADP+ to D-fructose + NADPH + H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.

Function

Mannitol 2-dehydrogenase (NADP+) is involved in the metabolic pathway known as fructose and mannose metabolism. It plays a crucial role in the conversion of D-mannitol, a type of sugar alcohol, into D-fructose, a monosaccharide or simple sugar. This process is essential for the metabolism of certain organisms, including some bacteria and fungi.

Structure

The structure of Mannitol 2-dehydrogenase (NADP+) is complex, with multiple subunits and a binding site for the cofactor NADP+. The enzyme's structure allows it to effectively catalyze the conversion of D-mannitol to D-fructose.

Clinical Significance

While Mannitol 2-dehydrogenase (NADP+) is not directly implicated in human disease, its role in fructose and mannose metabolism can have indirect effects on human health. For example, disruptions in fructose and mannose metabolism can lead to conditions such as fructose intolerance and mannosidosis.

See Also

• Mannitol
• Fructose
• NADP+
• Oxidoreductase
• Fructose intolerance
• Mannosidosis

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