Mast cell sarcoma

Mast cell sarcoma is a rare and aggressive form of mast cell disease. It is characterized by the presence of malignant mast cells in the skin, bone marrow, and other tissues.

Etiology

The exact cause of mast cell sarcoma is unknown. However, it is believed to be related to mutations in the KIT gene, which is responsible for the growth and development of mast cells.

Symptoms

Symptoms of mast cell sarcoma can vary widely, but often include skin lesions, anemia, fatigue, and weight loss. In some cases, the disease can also cause organomegaly, or enlargement of the organs.

Diagnosis

Diagnosis of mast cell sarcoma is typically made through a combination of physical examination, medical history, and laboratory tests. These tests may include a complete blood count, bone marrow biopsy, and immunohistochemistry to identify the presence of malignant mast cells.

Treatment

Treatment for mast cell sarcoma typically involves chemotherapy, radiation therapy, and in some cases, stem cell transplantation. The choice of treatment depends on the patient's overall health, the extent of the disease, and the patient's personal preferences.

Prognosis

The prognosis for mast cell sarcoma is generally poor, with a median survival time of less than a year. However, some patients may respond well to treatment and achieve long-term remission.

See also

• Mastocytosis
• Sarcoma
• Mast cell

NIH genetic and rare disease info

• NIH info on Mast cell sarcoma

Mast cell sarcoma is a rare disease.

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