Methacycline hydrochloride

Methacycline Hydrochloride is a tetracycline antibiotic used in the treatment of various bacterial infections. It is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria.

Chemical Structure

Methacycline Hydrochloride is a semi-synthetic derivative of tetracycline. It is chemically known as 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride.

Pharmacology

Methacycline Hydrochloride works by inhibiting protein synthesis in bacteria, thereby stopping their growth. It binds to the 30S ribosomal subunit of the bacteria, preventing the attachment of aminoacyl-tRNA to the mRNA-ribosome complex.

Clinical Use

Methacycline Hydrochloride is used to treat a variety of bacterial infections, including respiratory tract infections, skin infections, and urinary tract infections. It is also used in the treatment of acne due to its anti-inflammatory properties.

Side Effects

Like other tetracycline antibiotics, Methacycline Hydrochloride can cause a range of side effects. These include nausea, vomiting, diarrhea, and photosensitivity. Long-term use can lead to antibiotic resistance.

Precautions

Methacycline Hydrochloride should not be used in children under the age of 8, as it can cause permanent discoloration of the teeth. It should also be avoided during pregnancy and breastfeeding due to potential risks to the fetus or infant.

See Also

• Tetracycline
• Antibiotic resistance
• Protein synthesis