MicroRNA let-7a-2

MicroRNA let-7a-2 is a specific type of microRNA that plays a crucial role in the regulation of gene expression. It is part of the larger let-7 family of microRNAs, which are known for their involvement in various biological processes, including cell differentiation, proliferation, and apoptosis.

Structure and Function

MicroRNA let-7a-2 is a small, non-coding RNA molecule that functions in RNA silencing and post-transcriptional regulation of gene expression. It is encoded by the let-7a-2 gene, which is located on chromosome 11 in humans. The mature let-7a-2 microRNA is produced from a precursor molecule through the action of the Dicer enzyme.

The primary function of let-7a-2 is to regulate gene expression by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or translational repression. This allows let-7a-2 to control the levels of various proteins in the cell, influencing numerous cellular processes.

Role in Disease

Alterations in the expression of microRNA let-7a-2 have been associated with several diseases, particularly cancer. For instance, reduced levels of let-7a-2 have been observed in lung cancer, breast cancer, and colorectal cancer, suggesting a potential role as a tumor suppressor. Conversely, overexpression of let-7a-2 has been linked to autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

Therapeutic Potential

Given its involvement in disease, microRNA let-7a-2 is being explored as a potential therapeutic target. Strategies include the use of microRNA mimics or antagomirs to modulate the levels of let-7a-2 in the cell, with the aim of restoring normal gene expression patterns and cellular function.

File:MicroRNA let-7a-2 structure.jpg

Structure of microRNA let-7a-2

See Also

• MicroRNA
• Gene expression
• Cancer
• Autoimmune diseases

References

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