Mitochondrial pyruvate carrier 2

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Mitochondrial Pyruvate Carrier 2

Mitochondrial Pyruvate Carrier 2 (MPC2) is a protein that plays a crucial role in cellular metabolism by facilitating the transport of pyruvate into the mitochondria. Pyruvate is a key metabolite generated during glycolysis, and its transport into the mitochondria is essential for the production of energy through oxidative phosphorylation.

Function

MPC2 is part of the mitochondrial pyruvate carrier complex, which consists of two subunits: MPC1 and MPC2. Together, these subunits form a channel that allows pyruvate to enter the mitochondrial matrix, where it can be further metabolized to produce ATP.

Role in Metabolism

Pyruvate is a central metabolite that serves as a link between glycolysis and the citric acid cycle. By transporting pyruvate into the mitochondria, MPC2 helps to ensure a steady supply of substrates for ATP production. Disruption of MPC2 function can lead to metabolic imbalances and energy deficits in cells.

Clinical Implications

Mutations in the gene encoding MPC2 have been associated with metabolic disorders and mitochondrial dysfunction. Defects in MPC2 function can impair cellular energy production and contribute to the development of metabolic diseases.

Research

Studies investigating the role of MPC2 in cellular metabolism and disease have provided valuable insights into the importance of mitochondrial pyruvate transport. Further research is needed to fully understand the mechanisms underlying MPC2 function and its potential as a therapeutic target for metabolic disorders.

See also

• Mitochondrial pyruvate carrier
• Pyruvate
• Mitochondria

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