Mitragynine-pseudoindoxyl

Mitragynine-pseudoindoxyl

Mitragynine-pseudoindoxyl is a terpenoid indole alkaloid. It is a potent opioid analgesic substance found in the Mitragyna speciosa plant, also known as Kratom.

Chemistry

Mitragynine-pseudoindoxyl is a derivative of mitragynine, which is the most abundant alkaloid in the Mitragyna speciosa plant. The chemical structure of mitragynine-pseudoindoxyl includes a pseudoindoxyl ring, which is believed to contribute to its potent opioid activity.

Pharmacology

Mitragynine-pseudoindoxyl acts as an agonist at the mu-opioid receptor, with a higher binding affinity than morphine. It also acts as an antagonist at the delta-opioid receptor and the kappa-opioid receptor. The compound's opioid activity is thought to be responsible for the analgesic effects observed in animal studies.

Therapeutic Potential

Due to its potent opioid activity, mitragynine-pseudoindoxyl has been investigated for its potential use in the treatment of chronic pain. However, further research is needed to fully understand its safety and efficacy in humans.

Toxicity

The toxicity of mitragynine-pseudoindoxyl is not well-studied. However, due to its opioid activity, it is likely to have similar risks as other opioid drugs, including dependence and overdose.

See Also

• Mitragyna speciosa
• Mitragynine
• Opioid receptor