N-myc-interactor

N-myc-interactor (also known as NMI) is a protein that in humans is encoded by the NMI gene. NMI is a cytoplasmic protein that interacts with N-Myc and c-Myc (members of the Myc family of transcription factors), enhancing their transcriptional activity and stability.

Function[edit | edit source]

NMI is involved in several cellular processes, including cell cycle regulation, apoptosis, and cell differentiation. It interacts with several proteins, including STATs (signal transducers and activators of transcription), IFP35 (interferon-induced protein 35), and Myc proteins, to modulate their functions and regulate gene expression.

Clinical significance[edit | edit source]

Alterations in the expression of NMI have been associated with various types of cancer, including breast cancer, ovarian cancer, and lung cancer. It has been suggested that NMI may act as a tumor suppressor in certain types of cancer, but further research is needed to confirm this.

References[edit | edit source]

External links[edit | edit source]

NMI at the National Center for Biotechnology Information (NCBI)

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