NDUFB7

NDUFB7 is a protein that in humans is encoded by the NDUFB7 gene. The protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.

Function

NDUFB7 is an accessory subunit of the NADH:ubiquinone oxidoreductase (complex I) that is believed to be involved in the transfer of electrons from NADH to ubiquinone. Complex I is the first enzyme complex in the electron transport chain of mitochondria, which serves as the site of oxidative phosphorylation in eukaryotes.

Clinical significance

Mutations in the NDUFB7 gene are associated with mitochondrial complex I deficiency, a disorder that can cause a wide variety of clinical disorders, including Leigh syndrome, Leber's hereditary optic neuropathy, and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).

See also

• NADH dehydrogenase (ubiquinone)
• Electron transport chain
• Mitochondria

References

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian