Neamine
Neamine is a aminoglycoside antibiotic derived from Streptomyces fradiae. It is a component of the antibiotic neomycin and is composed of two ring structures, namely 2-deoxystreptamine and neosamine.
Chemical Structure[edit | edit source]
Neamine consists of two ring structures, 2-deoxystreptamine and neosamine. The 2-deoxystreptamine ring is a cyclohexane ring with two amino groups and one hydroxyl group. The neosamine ring is a pyranose ring with three hydroxyl groups and one amino group. These two rings are connected by a glycosidic bond.
Biosynthesis[edit | edit source]
Neamine is biosynthesized in Streptomyces fradiae through a series of enzymatic reactions. The biosynthesis begins with the formation of 2-deoxystreptamine from glucose and glutamine. This is followed by the addition of neosamine, which is derived from glucosamine-6-phosphate.
Pharmacology[edit | edit source]
Neamine exhibits antibacterial activity by binding to the ribosome and inhibiting protein synthesis. It is effective against a wide range of Gram-negative bacteria and some Gram-positive bacteria. However, due to its high toxicity, it is not used clinically. Instead, it is used as a starting material for the synthesis of other aminoglycoside antibiotics, such as neomycin.
See Also[edit | edit source]
- Need help finding a doctor or specialist anywhere in the world? WikiMD's DocFinder can help with millions of doctors!
This article is a stub. Help WikiMD grow by registering to expand it. |
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD