Nucleoporin 160
Nucleoporin 160 (NUP160) is a protein that in humans is encoded by the NUP160 gene. It is a component of the nuclear pore complex, a structure that regulates the transport of molecules between the nucleus and the cytoplasm in eukaryotic cells.
Function[edit | edit source]
NUP160 is one of the approximately 30 proteins that make up the nuclear pore complex. This complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. NUP160 is located on the cytoplasmic side of the nuclear pore complex and plays a crucial role in the import and export of proteins and RNAs, as well as the biogenesis of the nuclear envelope.
Structure[edit | edit source]
The NUP160 protein is a member of the Nup107-160 subcomplex, which also includes NUP107, NUP133, NUP85, NUP96, NUP37, SEH1, and SEC13. This subcomplex is thought to play a role in anchoring the nuclear pore complex to the nuclear envelope. The NUP160 protein itself is composed of multiple coiled-coil domains, which are thought to mediate protein-protein interactions.
Clinical significance[edit | edit source]
Mutations in the NUP160 gene have been associated with Spermatogenic failure 16, a condition characterized by male infertility due to a defect in sperm production.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD