Nucleoporin 43
Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene. It is a component of the nuclear pore complex, a structure that regulates the movement of molecules between the nucleus and the cytoplasm in eukaryotic cells.
Function[edit | edit source]
Nup43 is a member of the nucleoporin family, proteins that are the main constituents of the nuclear pore complex in eukaryotic cells. The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. Nup43 is a component of the nuclear pore complex central plug.
Clinical significance[edit | edit source]
Alterations in the nuclear pore complex, including changes in Nup43, have been associated with several human diseases, including cancer, cardiovascular disease, and neurodegenerative diseases.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD