Nucleoporin 93

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene. It is a component of the nuclear pore complex, a structure that regulates the movement of materials between the nucleus and the cytoplasm.

Function

Nup93 is a key component of the nuclear pore complex (NPC), which is a critical structure in cellular biology that regulates the transport of molecules between the nucleus and the cytoplasm. The NPC is composed of approximately 30 different proteins, known as nucleoporins, and Nup93 is one of these nucleoporins. It plays a crucial role in the assembly and stability of the NPC.

Structure

The NUP93 gene encodes a protein of 819 amino acids with a predicted molecular weight of approximately 93 kDa. The protein has a coiled coil domain in its N-terminal half and is predicted to be a transmembrane protein.

Clinical significance

Mutations in the NUP93 gene have been associated with a rare genetic disorder known as nephrotic syndrome, which is characterized by kidney damage. In addition, alterations in Nup93 function have been implicated in several types of cancer, including breast cancer and leukemia.

See also

• Nuclear pore
• Nucleoporin
• Nephrotic syndrome

References

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