Nucleoside analog

Nucleoside analogs are a group of antiviral or anticancer drugs. They are analogues of nucleosides which are the structural units of nucleic acids (DNA and RNA).

Mechanism of action

Nucleoside analogs inhibit the enzymes necessary for DNA and RNA synthesis, particularly DNA polymerase. They are incorporated into the growing DNA chain, causing premature termination.

Types

There are several types of nucleoside analogs, including:

• Cytarabine
• Gemcitabine
• Fludarabine
• Cladribine
• Clofarabine

Uses

Nucleoside analogs are used in the treatment of various diseases, including:

• Cancer
• Viral infections
• Hepatitis B
• Hepatitis C
• HIV/AIDS

Side effects

Common side effects of nucleoside analogs include:

• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Hair loss

See also

• Nucleotide analogs
• Antimetabolite
• Chemotherapy

Nucleoside analog Resources
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