P2RX5

P2RX5 is a gene that encodes the protein P2X purinoceptor 5 in humans. The protein is a member of the purinergic receptor family, a group of proteins that are sensitive to adenosine and ATP.

Function

The P2X receptors are a family of ligand-gated ion channels that allow the flow of cations across the cell membrane. These receptors are activated by the binding of ATP and are involved in a variety of physiological processes, including synaptic transmission, inflammation, and sensory transduction. The P2RX5 gene encodes a member of this family, the P2X5 receptor.

Structure

The P2X5 receptor is a trimeric ion channel, meaning it is composed of three subunits. Each subunit has two transmembrane domains, with both the N- and C-termini located intracellularly. The extracellular loop between the two transmembrane domains is where ATP binds to activate the receptor.

Expression

P2RX5 is expressed in a variety of tissues, including the immune, nervous, and reproductive systems. Within the immune system, P2RX5 is found on T cells, B cells, and macrophages, where it plays a role in immune response. In the nervous system, P2RX5 is involved in neurotransmission.

Clinical significance

Mutations in the P2RX5 gene have been associated with certain medical conditions. For example, a loss of function mutation in P2RX5 can lead to impaired immune response, as the receptor plays a crucial role in the activation of immune cells. Additionally, overexpression of P2RX5 has been observed in certain types of cancer, suggesting a potential role in tumorigenesis.

See also

• P2X receptor
• ATP
• Ion channel
• Immune system
• Nervous system
• Reproductive system

References

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian