PEPAP

PEPAP

PEPAP is a potent opioid analgesic drug that is structurally related to methadone. It was developed in the 1970s by a team at Upjohn company. PEPAP is a member of the 4-phenylpiperidine class of opioids. It is an analog of prodine and has a similar structure to pethidine (meperidine).

Chemistry

PEPAP, or 1-(2-phenylethyl)-4-phenyl-4-acetoxypiperidine, is a synthetic opioid that is structurally related to methadone. It is a white, crystalline substance that is soluble in water and ethanol. The chemical formula of PEPAP is C22H27NO2.

Pharmacology

PEPAP acts as a mu-opioid receptor agonist. It is a potent analgesic that is approximately 700 times more potent than morphine in animal models. The exact mechanism of action of PEPAP is not fully understood, but it is believed to work by binding to and activating the mu-opioid receptors in the brain, spinal cord, and other parts of the body. This reduces the perception of pain.

Clinical Use

PEPAP has been studied for its potential use in the treatment of severe pain. However, it has not been widely used in clinical practice due to concerns about its potential for abuse and addiction. Like other opioids, PEPAP has a high potential for abuse and can lead to physical dependence and addiction.

Side Effects

The side effects of PEPAP are similar to those of other opioids. These can include drowsiness, nausea, constipation, and respiratory depression. In addition, long-term use of PEPAP can lead to tolerance and physical dependence.

Legal Status

PEPAP is a Schedule II controlled substance in the United States, meaning it has a high potential for abuse and its use is severely restricted.

See Also

• Opioid
• Methadone
• Prodine
• Pethidine