PLD3

PLD3 (Phospholipase D family, member 3) is a protein that in humans is encoded by the PLD3 gene. It is a member of the phospholipase D (PLD) superfamily, which is involved in a variety of cellular processes, including cell signaling, membrane trafficking, and cytoskeleton rearrangements.

Function[edit | edit source]

PLD3 is a single-pass type II membrane protein. It does not possess PLD activity and does not influence phosphatidic acid production. The function of PLD3 is currently not well understood, but it is known to be highly expressed in neurons and astrocytes in the brain.

Clinical significance[edit | edit source]

Mutations in the PLD3 gene have been associated with late-onset Alzheimer's disease, although this association is controversial. Some studies have found a strong link between PLD3 mutations and Alzheimer's, while others have found no such link. Further research is needed to clarify the role of PLD3 in Alzheimer's disease.

References[edit | edit source]

External links[edit | edit source]

GeneCards - PLD3

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