Para-iodoamphetamine

Para-Iodoamphetamine (PIA), also known as 4-iodoamphetamine, is a research chemical of the phenethylamine and amphetamine chemical classes. It acts as a serotonin releasing agent and is also a MAO-A inhibitor. It is used in scientific research for mapping the usage of the serotonin transporter in the brain.

Chemistry[edit | edit source]

Para-Iodoamphetamine is a substituted amphetamine, meaning it is an amphetamine molecule which has been modified. In this case, it has been substituted with an iodine atom at the 4 position of the phenyl ring. This gives it its name, 4-iodoamphetamine.

Pharmacology[edit | edit source]

PIA acts as a serotonin releasing agent. This means it increases the levels of serotonin in the brain by inducing the release of stored serotonin from neurons. This can lead to a range of effects, including mood elevation and increased energy.

PIA is also a MAO-A inhibitor. MAO-A is an enzyme that breaks down serotonin, so by inhibiting this enzyme, PIA can further increase the levels of serotonin in the brain.

Uses[edit | edit source]

PIA is used in scientific research for mapping the usage of the serotonin transporter in the brain. It is not used in medicine due to its potential for abuse and lack of therapeutic benefits.

Safety[edit | edit source]

As a research chemical, PIA is not intended for human consumption. It has not been thoroughly tested, and its safety profile is not well understood. It is potentially toxic and may have a range of side effects.