Perphenazine enanthate

Perphenazine enanthate

Perphenazine enanthate is a long-acting ester of the phenothiazine derivative perphenazine. It is a potent antipsychotic used in the treatment of schizophrenia and other psychotic disorders.

Chemistry

Perphenazine enanthate is a synthetic compound derived from perphenazine. It is an ester of perphenazine, which is a phenothiazine derivative. The chemical structure of perphenazine enanthate includes a long-chain fatty acid, enanthic acid, linked to the nitrogen atom of the perphenazine molecule. This modification results in a drug with prolonged action.

Pharmacology

Perphenazine enanthate acts primarily by blocking dopamine receptors in the brain, specifically the D2 subtype. This action is thought to underlie its antipsychotic effects. It also has antimuscarinic effects and can block alpha-adrenergic receptors, which can lead to additional side effects.

Clinical use

Perphenazine enanthate is used in the treatment of chronic schizophrenia and other psychotic disorders. It is particularly useful in patients who have difficulty adhering to a regular medication schedule, as it can be administered once every two to four weeks.

Side effects

Common side effects of perphenazine enanthate include drowsiness, blurred vision, dry mouth, and constipation. More serious side effects can include tardive dyskinesia, a movement disorder, and neuroleptic malignant syndrome, a potentially life-threatening reaction to antipsychotic drugs.

See also

• Perphenazine
• Phenothiazine
• Antipsychotic