RPL23

RPL23 is a protein that in humans is encoded by the RPL23 gene. This protein is a component of the ribosome, a complex molecule responsible for DNA translation and protein synthesis in cells. The RPL23 gene is part of the large ribosomal protein family, which plays a critical role in the cellular process of translating mRNA into proteins. Ribosomal proteins, including RPL23, are essential for the proper assembly and function of ribosomes, making them crucial for the growth and division of cells.

Function

RPL23 is involved in the early stages of ribosome assembly and is located in the 60S subunit of the ribosome. It interacts with other ribosomal proteins and ribosomal RNA (rRNA) to contribute to the structural stability of the ribosome and facilitate the fidelity of protein translation. The protein is also implicated in various cellular processes beyond its structural role in the ribosome, including playing a part in the cellular response to stress and in the regulation of apoptosis.

Clinical Significance

Alterations in the expression levels of RPL23 have been observed in various types of cancer, suggesting that it may play a role in tumorigenesis. Overexpression of RPL23 has been linked to the development and progression of certain cancers, making it a potential target for cancer therapy. Additionally, due to its role in protein synthesis and cell growth, RPL23 is being studied for its potential implications in diseases related to ribosome dysfunction, known as ribosomopathies.

Genetic Information

The RPL23 gene is located on chromosome 5 in humans. Like other ribosomal protein genes, RPL23 is characterized by its high degree of conservation across different species, highlighting the fundamental role of ribosomal proteins in cellular function.

See Also

• Ribosome
• Protein synthesis
• Ribosomal proteins
• Cellular stress