Recombinant human nerve growth factor

Recombinant Human Nerve Growth Factor

File:NGF protein structure.png

Structure of the nerve growth factor (NGF).

The Recombinant Human Nerve Growth Factor (rhNGF) is a protein that is crucial for the growth, maintenance, and survival of certain nerve cells (neurons). It is a type of neurotrophin released by cells that helps to stimulate and control neurogenesis, the process of nerve cell growth and development.

Structure and Function

The rhNGF is a dimer composed of two identical 118 amino acid subunits, which are held together by disulfide bridges. The protein is encoded by the NGF gene, which is located on chromosome 1 in humans.

The primary role of rhNGF is to promote the survival and differentiation of neurons, particularly sensory and sympathetic neurons. It achieves this by binding to and activating the TrkA receptor, a type of tyrosine kinase receptor found on the surface of these neurons.

Clinical Significance

Due to its role in nerve growth and maintenance, rhNGF has been studied for potential therapeutic applications in a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. It has also been investigated for use in the treatment of peripheral neuropathy, a condition that results in the damage to the peripheral nerves.

See Also

• Nerve growth factor
• Neurotrophin
• Neurogenesis
• Neurodegenerative disease

References

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