Ring finger protein 19B

Ring Finger Protein 19B (RNF19B) is a protein that in humans is encoded by the RNF19B gene. The protein encoded by this gene is a member of the RING finger protein family, a group of proteins characterized by a unique structural motif known as the RING finger domain.

Function

The RNF19B protein is a E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein plays a role in the control of protein degradation and protein homeostasis.

Clinical significance

Alterations in the RNF19B gene have been associated with various diseases. For instance, mutations in this gene have been linked to neurodegenerative diseases due to the protein's role in the degradation of misfolded proteins.

Structure

The RNF19B protein contains a RING finger domain, which is a zinc-binding domain found in a variety of proteins. The RING finger domain is responsible for the protein's E3 ubiquitin ligase activity.

See also

• RING finger domain
• E3 ubiquitin-protein ligase
• Ubiquitin
• Protein degradation

References

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