Roger D. Kornberg

Roger.Kornberg

Vice President Dick Cheney meets with the 2006 U.S. Nobel Laureates, Thursday, November 30, 2006

Roger D. Kornberg (born April 24, 1947) is an American biochemist and professor at Stanford University. He was awarded the Nobel Prize in Chemistry in 2006 for his work on the molecular basis of eukaryotic transcription, a process in which DNA is copied to RNA. Kornberg's research has been pivotal in understanding the mechanism by which genetic information from DNA is transcribed to messenger RNA, a key step in the central dogma of molecular biology that dictates the flow of genetic information from DNA to RNA to protein.

Early Life and Education

Roger D. Kornberg was born in St. Louis, Missouri, to a family deeply rooted in scientific research. His father, Arthur Kornberg, was a Nobel Laureate in Medicine, awarded in 1959 for his work on the biological synthesis of DNA. Roger Kornberg followed in his father's footsteps, pursuing a career in the biological sciences. He earned his Bachelor of Science degree in chemistry from Harvard University in 1967 and went on to complete his Ph.D. in chemical physics at Stanford University in 1972.

Career and Research

After completing his Ph.D., Kornberg conducted postdoctoral research at the Laboratory of Molecular Biology in Cambridge, England. He then returned to the United States, where he joined the faculty at Stanford University. Over the years, Kornberg has made significant contributions to the field of biochemistry, particularly in understanding the process of transcription in eukaryotic cells.

His Nobel Prize-winning research elucidated how the enzyme RNA polymerase II reads the DNA code and initiates the synthesis of messenger RNA. This work not only provided a detailed picture of the transcription mechanism but also shed light on how gene expression is regulated in cells. Kornberg's discoveries have had profound implications for medical research, including the understanding of cancer and other diseases caused by abnormalities in gene expression.

Awards and Honors

In addition to the Nobel Prize, Roger D. Kornberg has received numerous awards and honors for his contributions to science. These include the Louisa Gross Horwitz Prize from Columbia University and the Lefoulon-Delalande Grand Prize from the French Academy of Sciences. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences.

Personal Life

Roger D. Kornberg is married and has three children. He has maintained a lifelong commitment to scientific research and education, following in the legacy of his father, Arthur Kornberg.

Legacy and Impact

Roger D. Kornberg's work has fundamentally advanced our understanding of the molecular mechanisms governing transcription. By revealing how RNA polymerase II functions and how transcription is regulated, Kornberg has laid the groundwork for future research in genetics, molecular biology, and medicine. His discoveries continue to influence the development of new therapeutic strategies for treating diseases related to gene expression.