SB-334,867

SB-334867 is a drug that is used primarily in scientific research. It acts as a selective, non-peptide antagonist at the orexin receptor subtype OX1, with around 50x selectivity over subtype OX2.

Pharmacology[edit | edit source]

SB-334867 was the first non-peptide antagonist developed that is selective for the orexin receptor. The orexin system was initially identified as a central promoter of wakefulness, but has since been found to regulate a wide variety of behaviors. SB-334867 has been used in a variety of animal studies to explore the role of the orexin system in behavior.

Chemistry[edit | edit source]

SB-334867 is a phenyl piperazine derivative, with a trifluoromethyl group on the phenyl ring, and a urea group linking the piperazine ring to a naphthalene moiety.

Uses in research[edit | edit source]

SB-334867 has been used in a variety of research contexts to investigate the role of the orexin system in regulating a variety of behaviors. These include studies on feeding behavior, sleep-wake cycles, reward seeking, and drug addiction.