SOCS4

SOCS4 or Suppressor of Cytokine Signaling 4 is a protein that in humans is encoded by the SOCS4 gene. It is a member of the Suppressor of Cytokine Signaling (SOCS) family, a group of proteins known for their role in regulating the immune response.

Function

SOCS4, like other members of the SOCS family, is involved in the negative regulation of cytokine signaling. Cytokines are small proteins that play crucial roles in cell signaling, and their regulation is essential for maintaining homeostasis in the body. SOCS4 can bind to JAK (Janus kinase) proteins and inhibit their activity, thereby preventing excessive cytokine signaling.

Clinical Significance

Research has suggested that SOCS4 may play a role in various diseases, including cancer. Some studies have found that SOCS4 is downregulated in certain types of cancer, suggesting that it may act as a tumor suppressor. However, more research is needed to fully understand the role of SOCS4 in disease.

See Also

• SOCS1
• SOCS2
• SOCS3
• Cytokine
• Janus kinase

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