Shc Binding And Spindle Associated 1 Like

Shc Binding and Spindle Associated 1 Like (SHCBP1L), also known as Shc SH2-domain binding protein 1 like, is a protein that in humans is encoded by the SHCBP1L gene. This protein plays a crucial role in cell division and is particularly involved in the spindle checkpoint during mitosis. The SHCBP1L protein interacts with various components of the cell to ensure accurate chromosome segregation, thereby preventing genetic disorders and cancer development.

Function

SHCBP1L is implicated in the regulation of mitotic spindle assembly and is essential for proper chromosome segregation during cell division. It interacts with the SHC (Src Homology 2 Domain Containing) family proteins, which are known to play roles in signal transduction pathways that regulate cellular proliferation, differentiation, and survival. The interaction between SHCBP1L and SHC proteins suggests that SHCBP1L might also be involved in these pathways, particularly in the context of cell division.

Gene

The SHCBP1L gene is located on human chromosome 22. It consists of multiple exons and encodes the SHCBP1L protein. The gene's expression is tightly regulated, with significant upregulation observed during mitosis, indicating its critical role in cell cycle progression.

Clinical Significance

Alterations in the expression or function of SHCBP1L have been associated with various types of cancer. Overexpression of SHCBP1L has been observed in certain cancers and is thought to contribute to tumorigenesis by promoting excessive cell division. As such, SHCBP1L is being studied as a potential target for cancer therapy, with the aim of developing treatments that can inhibit its function and thus slow down or stop the growth of cancer cells.

Research

Research on SHCBP1L is ongoing, with studies focusing on its role in cell division and its potential as a therapeutic target in cancer. Understanding the precise mechanisms by which SHCBP1L functions and its interactions with other proteins in the cell can provide insights into not only cancer biology but also the fundamental processes of cell division and genetic stability.

See Also

• Cell division
• Mitosis
• Chromosome
• Cancer
• Gene
• Protein

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