Small nucleolar rna host gene 1
Small Nucleolar RNA Host Gene 1 (SNHG1) is a gene that in humans is encoded by the SNHG1 gene. It is a long non-coding RNA gene, and is also known as U22HG (U22 Host Gene).
Function[edit | edit source]
Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs which are associated with methylation, and the H/ACA box snoRNAs which are associated with pseudouridylation.
SNHG1 is a host gene for a number of C/D box snoRNAs, meaning it is the gene from which these snoRNAs are transcribed. These snoRNAs are located in the introns, the non-coding regions, of the SNHG1 gene.
Clinical Significance[edit | edit source]
Alterations in the SNHG1 gene have been associated with a number of cancer types, including colorectal cancer, hepatocellular carcinoma, and breast cancer. It is thought that the SNHG1 gene may play a role in tumorigenesis and cancer progression, although the exact mechanisms are not yet fully understood.
See Also[edit | edit source]
References[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD