Solute carrier organic anion transporter family member 2A1
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) is a protein that in humans is encoded by the SLCO2A1 gene. This protein is a member of the solute carrier family, specifically the organic anion transporting polypeptides. These proteins are involved in the transport of various compounds across the cell membrane.
Function[edit | edit source]
The SLCO2A1 gene encodes a protein that is a member of the solute carrier family. This family of proteins is responsible for the transport of a wide variety of substrates across the cell membrane. The protein encoded by SLCO2A1 is specifically involved in the transport of organic anions. These organic anions can include a variety of compounds, such as bile acids, thyroid hormones, and conjugated steroids.
Clinical significance[edit | edit source]
Mutations in the SLCO2A1 gene have been associated with several medical conditions. These include primary hypertrophic osteoarthropathy, a rare genetic disorder characterized by digital clubbing, periostosis, and pachydermia, and chronic nonspecific multiple ulcers of small intestine, a rare disorder characterized by multiple small intestinal ulcers of nonspecific origin.
See also[edit | edit source]
- Solute carrier family
- Organic anion transporting polypeptide
- Primary hypertrophic osteoarthropathy
- Chronic nonspecific multiple ulcers of small intestine
References[edit | edit source]
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