Somatostatin receptor 2
Somatostatin receptor 2 (SSTR2) is a protein that in humans is encoded by the SSTR2 gene. It is one of the five somatostatin receptors.
Function[edit | edit source]
Somatostatin receptor 2 is a G protein-coupled receptor that inhibits the release of somatotropin, also known as growth hormone. It is expressed in the pancreas, kidney, prostate, and adrenal gland, among other tissues.
Clinical significance[edit | edit source]
Mutations in the SSTR2 gene have been associated with neuroendocrine tumors. The receptor is also a target for octreotide, a drug used to treat acromegaly and neuroendocrine tumors.
Structure[edit | edit source]
The SSTR2 gene is located on the long arm of chromosome 17 (17q24). The protein encoded by this gene is a 369 amino acid protein with seven transmembrane domains, characteristic of G protein-coupled receptors.
Ligands[edit | edit source]
Several ligands have been developed for SSTR2, including octreotide, lanreotide, and pasireotide. These drugs are used to treat conditions such as acromegaly and neuroendocrine tumors.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD