Sticky platelet syndrome
Sticky platelet syndrome is a term used by some [1][2][3][4] to describe a disorder of platelet function.[5] It was first described by Mammen in 1983.[6] It is inherited in an autosomal dominant pattern.[7] It has not been associated with a specific gene, and it is not recognized as an entity in OMIM.
Among researchers using the term, it has been described as a coagulation disorder that can present in conjunction with protein S deficiency and Factor V Leiden.[8] It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder.
Cause[edit | edit source]
The syndrome is believed to be hereditary.[9]
Diagnosis[edit | edit source]
SPS is diagnosed by demonstrating platelet hyperaggregability. In a lab test called aggregometry platelet stickiness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP).[10] This test is not possible for patients being treated with acetylsalicylic acid until that substance has sufficiently cleared from their system. [citation needed]
Treatment[edit | edit source]
Those diagnosed are usually treated with taking a low dose (80–100 mg) Aspirin a day.[11] Anticoagulants (e.g. Warfarin, Coumadin) or clopidogrel (Plavix) are often additionally prescribed following formation of a medically significant clot. Thrombelastography is more commonly being used to diagnose hypercoagulability and monitor anti-platelet therapy. [citation needed]
See also[edit | edit source]
References[edit | edit source]
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