Syntaxin-2

Syntaxin-2 is a protein that in humans is encoded by the STX2 gene. Syntaxin-2 is a member of the syntaxin family, which are integral membrane proteins that are involved in the transport of vesicles in the cell.

Function

Syntaxin-2 is a t-SNARE protein that is primarily located in the plasma membrane, where it plays a crucial role in the process of membrane fusion. It forms a complex with other SNARE proteins to mediate the fusion of vesicles with the target membrane. This process is essential for a variety of cellular functions, including neurotransmitter release, hormone secretion, and cell growth.

Structure

The structure of Syntaxin-2 is characterized by a SNARE motif, a transmembrane domain, and an N-terminal Habc domain. The SNARE motif is involved in the formation of the SNARE complex, while the transmembrane domain anchors the protein to the plasma membrane. The Habc domain is thought to regulate the interaction of Syntaxin-2 with other proteins.

Clinical significance

Mutations in the STX2 gene have been associated with a variety of diseases, including Alzheimer's disease, Parkinson's disease, and certain types of cancer. In addition, Syntaxin-2 has been implicated in the pathogenesis of infectious diseases, as some pathogens have been found to manipulate the function of this protein to facilitate their own replication.

See also

• Syntaxin
• SNARE (protein)
• Membrane fusion

References

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