TNNI3K

TNNI3K (TNNI3 Interacting Kinase) is a protein that in humans is encoded by the TNNI3K gene. This protein is a cardiac-specific kinase that is thought to play a critical role in cardiac development and function.

Function

TNNI3K is a cardiac-specific kinase that can phosphorylate cardiac troponin I (TNNI3) and other proteins. It has been suggested to play a role in cardiac function and response to myocardial infarction. The TNNI3K gene is thought to influence the risk of congestive heart failure.

Clinical significance

Mutations in the TNNI3K gene have been associated with familial dilated cardiomyopathy, a condition characterized by an enlarged and weakened heart muscle. This can result in heart failure and other complications.

Research

Research into TNNI3K has suggested that it may be a potential therapeutic target for the treatment of heart failure. Studies have shown that inhibition of TNNI3K can reduce cardiac remodeling and improve heart function in animal models of heart failure.

See also

• Cardiac muscle
• Cardiomyopathy
• Heart failure
• Troponin

External links

• NCBI Gene
• UniProt

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