TONSL

TONSL is a protein that in humans is encoded by the TONSL gene. It is involved in the DNA repair process and plays a crucial role in maintaining the stability of the human genome.

Function

TONSL is a protein that is involved in the DNA repair process. It is known to bind to histones, which are proteins that package and order the DNA into structural units called nucleosomes. This binding is particularly strong when the histones are marked by a specific chemical tag, known as methylation.

TONSL is also involved in the repair of DNA damage caused by ionizing radiation. It is thought to do this by helping to recruit other proteins to the site of DNA damage, thereby facilitating the repair process.

Clinical significance

Mutations in the TONSL gene have been associated with an increased risk of developing certain types of cancer, including breast cancer and ovarian cancer. This is likely due to the role of TONSL in DNA repair. When this process is disrupted, it can lead to the accumulation of DNA damage, which can in turn lead to the development of cancer.

Research

Research into TONSL is ongoing, with scientists seeking to better understand its role in DNA repair and its potential as a target for cancer therapy.

See also

• DNA repair
• Histone
• Nucleosome
• Methylation
• Ionizing radiation
• Cancer

References

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