TPSG1

TPSG1 or Tryptase gamma 1 is a protein that in humans is encoded by the TPSG1 gene. This protein is a member of the serine protease family. TPSG1 is expressed in mast cells and is thought to function in the degradation of extracellular matrix, the regulation of peripheral nervous system development, and the formation of blood vessels.

Function

The TPSG1 gene encodes a tryptase, which is a member of the serine protease family. Tryptases are proteolytic enzymes that cleave peptide bonds in proteins. They are stored in the secretory granules of mast cells and are secreted in response to stimuli such as allergens and inflammation. Tryptases have been implicated in a variety of physiological and pathological processes, including the regulation of immune response, inflammation, and tissue remodeling.

Structure

The TPSG1 protein is a tetramer, composed of four identical subunits. Each subunit is composed of a single polypeptide chain, which is folded into a compact, globular structure. The active site of the enzyme, where the proteolytic cleavage of peptide bonds occurs, is located in a deep pocket in the center of the molecule.

Clinical significance

Mutations in the TPSG1 gene have been associated with a variety of diseases, including asthma, atopic dermatitis, and nasal polyps. In addition, elevated levels of TPSG1 have been found in the blood of patients with systemic mastocytosis, a disease characterized by an excessive number of mast cells.

See also

• Serine protease
• Mast cell
• Gene
• Protein

References

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