Taurolithocholic acid

Taurolithocholic acid

Taurolithocholic acid is a bile acid derived from lithocholic acid. It is a conjugate of lithocholic acid with the amino acid taurine. Taurolithocholic acid plays a crucial role in the digestion and absorption of fats in the human body.

Structure

Taurolithocholic acid has a molecular formula of C26H45NO6S and a molecular weight of 499.7 g/mol. It is a secondary bile acid formed by the conjugation of lithocholic acid with taurine.

Function

Taurolithocholic acid aids in the emulsification and absorption of dietary fats in the small intestine. It facilitates the solubilization of lipids and fat-soluble vitamins, allowing for their uptake by the body.

Metabolism

In the liver, taurolithocholic acid is synthesized through the conjugation of lithocholic acid with taurine. It is then released into the bile and stored in the gallbladder. Upon ingestion of food, taurolithocholic acid is secreted into the small intestine to aid in fat digestion.

Clinical Significance

Abnormal levels of taurolithocholic acid in the body can be indicative of liver or gallbladder disorders. Elevated levels may suggest impaired bile acid metabolism or cholestasis.

References

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