Trafficking protein particle complex 6a

Trafficking protein particle complex 6A (TRAPPC6A) is a protein that in humans is encoded by the TRAPPC6A gene. This protein is a component of the TRAPP complex, which is involved in intracellular trafficking and protein transport within the cell.

Function

The TRAPPC6A protein is a part of the TRAPP complex, which functions in vesicle transport within the cell. This complex is involved in the transport of proteins from the endoplasmic reticulum to the Golgi apparatus, and from the Golgi to other parts of the cell. The TRAPPC6A protein specifically is thought to play a role in the transport of proteins to the cell surface.

Structure

The TRAPPC6A protein is composed of 142 amino acids and has a molecular weight of approximately 16 kDa. It contains a conserved domain of unknown function (DUF1394), which is found in several other proteins involved in vesicle transport.

Clinical significance

Mutations in the TRAPPC6A gene have been associated with a rare genetic disorder known as mental retardation, autosomal dominant 31 (MRD31). This condition is characterized by intellectual disability and developmental delay.

See also

• TRAPP
• Protein transport
• Endoplasmic reticulum
• Golgi apparatus

References

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