UBE2V1

Protein UBE2V1 PDB 1j74

UBE2V1

UBE2V1 is a gene that encodes a protein involved in the ubiquitination process. This gene is located on chromosome 1 in humans. The protein encoded by UBE2V1 is a member of the ubiquitin-conjugating enzyme family, which plays a crucial role in tagging proteins for degradation.

Function

The UBE2V1 protein functions as an E2 ubiquitin-conjugating enzyme, working in conjunction with E3 ubiquitin ligases to transfer ubiquitin molecules to target proteins. This process marks the target proteins for degradation by the proteasome, a cellular machinery responsible for breaking down unwanted or damaged proteins.

Structure

The UBE2V1 protein consists of a conserved catalytic domain that interacts with ubiquitin and forms a thioester bond during the ubiquitination process. It also contains a flexible N-terminal extension that is important for its interaction with specific E3 ligases.

Role in Disease

Mutations in the UBE2V1 gene have been associated with certain diseases, including cancer. Dysregulation of the ubiquitination process can lead to abnormal protein turnover and contribute to the development of various disorders.

Interactions

The UBE2V1 protein interacts with a variety of E3 ligases, such as Cullin-RING ligases, to facilitate the transfer of ubiquitin to target proteins. These interactions are essential for the proper functioning of the ubiquitination pathway.