UFSP2

UFSP2 (Ufm1-specific protease 2) is a protein that in humans is encoded by the UFSP2 gene. This protein is part of the ubiquitin-like modifier system, which is involved in cellular processes such as protein degradation, DNA repair, and cell cycle regulation.

Function

The UFSP2 protein is a cysteine protease that specifically cleaves Ufm1, a ubiquitin-like protein. This cleavage is necessary for Ufm1 to be conjugated to its target proteins. The UFSP2 protein is therefore essential for the function of the Ufm1 system.

Clinical significance

Mutations in the UFSP2 gene have been associated with Beukes hip dysplasia, a rare genetic disorder characterized by premature degenerative osteoarthritis of the hip.

See also

• Ufm1
• Ubiquitin
• Protease
• Beukes hip dysplasia

References

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