Ethyl loflazepate
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Ethyl loflazepate is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative, and muscle relaxant properties. It is primarily used in the treatment of anxiety disorders and insomnia. Ethyl loflazepate is known for its long-acting effects and is metabolized into active metabolites, which contribute to its prolonged duration of action.
Pharmacology[edit | edit source]
Ethyl loflazepate works by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, which results in its calming effects on the central nervous system. This action helps to reduce anxiety, induce sleep, and relax muscles.
Medical Uses[edit | edit source]
Ethyl loflazepate is prescribed for:
Side Effects[edit | edit source]
Common side effects of ethyl loflazepate include:
- Drowsiness
- Dizziness
- Fatigue
- Ataxia (lack of muscle coordination)
Serious side effects may include:
- Respiratory depression
- Dependence and withdrawal symptoms
- Cognitive impairment
Contraindications[edit | edit source]
Ethyl loflazepate should not be used in individuals with:
Interactions[edit | edit source]
Ethyl loflazepate can interact with other central nervous system depressants, such as:
Metabolism[edit | edit source]
Ethyl loflazepate is metabolized in the liver to active metabolites, including desmethyldiazepam, which contribute to its long-lasting effects. The metabolites are excreted primarily through the kidneys.
Legal Status[edit | edit source]
The legal status of ethyl loflazepate varies by country. In some regions, it is classified as a controlled substance due to its potential for abuse and dependence.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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