YWHAQ

YWHAQ is a gene that encodes the protein 14-3-3 protein theta in humans. This protein is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins.

Function

The protein encoded by the YWHAQ gene is a member of the 14-3-3 family of proteins. These proteins are highly conserved and are found in all eukaryotic organisms. They play a key role in cell cycle control, apoptosis, signal transduction pathways, and cellular stress responses. The 14-3-3 proteins bind to a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors.

Structure

The 14-3-3 proteins are characterized by their ability to bind to phosphoserine-containing proteins. They have a highly conserved structure, with each protein consisting of nine antiparallel alpha helices. The YWHAQ protein, like other 14-3-3 proteins, forms a cup-like structure that allows it to bind to its target proteins.

Clinical significance

Mutations in the YWHAQ gene have been associated with a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. In cancer, overexpression of the YWHAQ protein has been observed in several types of tumors, suggesting that it may play a role in tumor progression. In neurodegenerative diseases, the YWHAQ protein has been implicated in the regulation of tau protein, which is involved in the formation of neurofibrillary tangles in Alzheimer's disease.

File:14-3-3 protein theta.png

Structure of the 14-3-3 protein theta encoded by the YWHAQ gene.

See also

• 14-3-3 protein
• Signal transduction
• Cell cycle
• Apoptosis

References

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