SIN3B

SIN3B is a protein that in humans is encoded by the SIN3B gene. The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.

Function

SIN3B is a master regulator of gene expression and is involved in numerous biological processes. It is a core component of the SIN3 histone deacetylase (HDAC) complex, which plays a key role in regulating eukaryotic gene expression. The SIN3B-HDAC complex is a critical component of the transcriptional repression machinery and is involved in many cellular processes, including cell cycle regulation, apoptosis, and differentiation.

Clinical Significance

Alterations in the function of SIN3B have been implicated in a variety of diseases, including cancer. For example, aberrant expression of SIN3B has been observed in several types of cancer, including breast cancer and colorectal cancer. In addition, mutations in the SIN3B gene have been associated with an increased risk of developing certain types of cancer.

Research

Research into the function of SIN3B and its role in disease is ongoing. Current research efforts are focused on understanding the molecular mechanisms by which SIN3B regulates gene expression and contributes to disease development and progression. This research may lead to the development of new therapeutic strategies for diseases associated with alterations in SIN3B function.

See Also

• SIN3A
• Histone deacetylase
• Transcription (genetics)

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