Corticotropin-releasing hormone receptor 1

Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein that in humans is encoded by the CRHR1 gene. It is one of the two main types of corticotropin-releasing hormone receptors. CRHR1 is a G protein-coupled receptor that binds neuropeptides of the corticotropin-releasing hormone family to trigger various physiological responses.

Function

CRHR1 is primarily responsible for the stress response in the body. When activated by corticotropin-releasing hormone (CRH), it stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH then triggers the adrenal glands to produce and release cortisol, a hormone that helps the body respond to stress.

Clinical significance

Alterations in CRHR1 function have been associated with a variety of disorders, including major depressive disorder, post-traumatic stress disorder, alcoholism, and anxiety disorders. Certain polymorphisms in the CRHR1 gene have been linked to these conditions, suggesting a genetic component to susceptibility.

See also

• Corticotropin-releasing hormone receptor
• Corticotropin-releasing hormone
• G protein-coupled receptor
• Stress (biology)

References

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