Estradiol palmitate
Estradiol Palmitate is a synthetic, steroidal estrogen that is a long-lasting estrogen ester. It is a prodrug of estradiol, and is administered by injection into muscle.
Pharmacology[edit | edit source]
Estradiol palmitate is a prodrug of estradiol, meaning it is metabolized in the body into estradiol. It is a long-lasting estrogen ester, providing a prolonged duration of effect compared to estradiol itself. This is due to the slow release of estradiol from the ester in the body.
Medical Uses[edit | edit source]
Estradiol palmitate is used in hormone therapy for menopausal symptoms and low estrogen levels. It is also used in feminizing hormone therapy for transgender women.
Side Effects[edit | edit source]
Like all estrogens, estradiol palmitate can have a number of side effects, including nausea, bloating, breast tenderness, and an increased risk of blood clots and stroke. It can also cause changes in menstrual periods and mood changes.
History[edit | edit source]
Estradiol palmitate was first described in the literature in 1953. It has been used in medicine since at least the 1960s.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD