GRIK3

GRIK3 or Glutamate Ionotropic Receptor Kainate Type Subunit 3 is a protein that in humans is encoded by the GRIK3 gene. It is a member of the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.

Function[edit | edit source]

The protein encoded by this gene is a subunit of a kainate glutamate receptor. Glutamate receptors mediate the majority of excitatory neurotransmission in the brain. This receptor may have a role in synaptic plasticity, a process that underlies learning and memory. It is thought to interact with other proteins, like Neto1 and Neto2, to regulate kainate receptor function.

Clinical significance[edit | edit source]

Alterations in the gene encoding GRIK3 have been associated with bipolar disorder and schizophrenia. It has also been associated with recurrent major depressive disorder.

Structure[edit | edit source]

The GRIK3 protein is a transmembrane protein, meaning it spans the membrane of the cells in which it is expressed. It is composed of several domains, including an extracellular amino terminal domain, a ligand-binding domain, a transmembrane domain, and an intracellular carboxy terminal domain.