Interleukin-11 receptor
Interleukin-11 receptor (IL-11R) is a type of protein that is encoded by the IL11RA gene in humans. It is a part of the interleukin receptor family, which plays a crucial role in the immune system and inflammatory response.
Structure[edit | edit source]
The IL-11R is a transmembrane protein that is primarily expressed on the surface of hematopoietic cells. It consists of two subunits: the alpha subunit (IL-11Rα) and the beta subunit (IL-11Rβ). The alpha subunit is specific to IL-11, while the beta subunit is shared with other cytokine receptors.
Function[edit | edit source]
The primary function of the IL-11R is to bind with interleukin-11 (IL-11), a cytokine that plays a key role in hematopoiesis and immune response. Upon binding with IL-11, the receptor activates the JAK/STAT signaling pathway, leading to the transcription of target genes that regulate cell growth, differentiation, and apoptosis.
Clinical Significance[edit | edit source]
Mutations in the IL11RA gene can lead to abnormalities in the IL-11R, which can result in various diseases. For instance, a deficiency in IL-11Rα has been associated with Craniosynostosis and dental anomalies. Moreover, overexpression of IL-11R has been observed in several types of cancer, including breast cancer and gastric cancer, suggesting a potential role in tumor progression.
Research[edit | edit source]
Research on IL-11R is ongoing, with studies focusing on its role in health and disease, as well as its potential as a therapeutic target. For example, IL-11R antagonists are being explored as potential treatments for conditions such as rheumatoid arthritis and cancer.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD