O-Toluidine

Metabolism toluidine

o-Toluidine is an organic compound with the chemical formula C_7H_9N. It is one of the three isomers of toluidine, the others being m-toluidine and p-toluidine. o-Toluidine is a colorless to pale yellow liquid with a characteristic odor. It is slightly soluble in water but miscible with ethanol, ether, and benzene.

Production

o-Toluidine is produced industrially by the reduction of o-nitrotoluene using hydrogen in the presence of a catalyst such as iron or nickel. This process is known as catalytic hydrogenation.

Applications

o-Toluidine is primarily used in the production of dyes, particularly azo dyes, which are used in the textile and leather industries. It is also used as an intermediate in the synthesis of herbicides, pesticides, and pharmaceuticals.

Health and Safety

o-Toluidine is classified as a carcinogen and poses significant health risks upon exposure. It can be absorbed through the skin, inhaled, or ingested, leading to symptoms such as headache, dizziness, nausea, and methemoglobinemia. Long-term exposure can result in damage to the liver and kidneys.

Environmental Impact

o-Toluidine can be harmful to the environment, particularly to aquatic life. It is important to handle and dispose of this chemical properly to minimize its environmental impact.

See also

• Toluidine
• Azo dye
• Carcinogen
• Catalytic hydrogenation

References

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