MC1R

MC1R

The Melanocortin 1 receptor (MC1R) also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor is a protein that in humans is encoded by the MC1R gene. MC1R is a G protein-coupled receptor located on the surface of melanocytes.

Function

MC1R is a receptor for melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). It is a major determinant of skin pigmentation, hair color, and immune response. Activation of MC1R increases the production of melanin, which provides protection against UV radiation and oxidative stress.

Clinical significance

Variations in the MC1R gene are associated with red hair color, pale skin, freckling, and increased risk of skin cancer. Certain MC1R variants are also associated with the response to pain and inflammation.

See also

• Melanocortin receptor
• Melanocyte-stimulating hormone
• Adrenocorticotropic hormone
• Melanin
• Skin pigmentation
• Red hair
• Skin cancer

External links

• MC1R at the US National Library of Medicine Medical Subject Headings (MeSH)

MC1R Resources
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